Hao Laboratory

Our primary research interest is to understand the pattern of genomic changes and mutational processes, and their corresponding functional consequences. To accomplish this research, we conduct comparative genomic studies using next-generation sequencing, experimental and bioinformatics approaches. Much of our published work has been carried out on bacteria, yeast and fungi.

We plan to continue the investigation of molecular mechanisms underlying variable genome architecture:

1) Mechanisms of genetic mutation.
2) Gain and loss of genes and gene networks.
3) Development of antibiotic resistance.